Thursday, October 3, 2013
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Combined microscopy system
to image tumors during tissue-conserving surgery
A combined autofluorescence
and Raman scattering microscopy system could help with the rapid
identification of tumor regions during tissue-conserving surgery without a
tissue preparation step. The system relies on an automated sampling strategy
that uses autofluorescence imaging to select and prioritize areas for Raman
spectroscopy. In patient skin tissue samples, the combined system enabled
diagnosis of basal cell carcinoma (BCC) regions with 100% sensitivity and 92%
specificity. The total time to diagnosis for the combined method was
estimated at 20-60 minutes, whereas frozen-section histopathology has a 45-120
minute tissue preparation step plus another 10-15 minute diagnosis step. Next
steps could include further optimizing the speed and accuracy of the approach
and evaluating it in clinical trials.
Published online Oct. 3, 2013
Patent application filed;
licensing status unavailable
Kong, K. et al. Proc.
Natl. Acad. Sci. USA; published online Sept. 3, 2013;
Contact: Ioan Notingher, The University of Nottingham, Nottingham,
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