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Mice overexpressing kidney injury molecule 1 (Kim-1) to model chronic kidney disease (CKD)

Mice that chronically overexpress Kim-1 in renal epithelial cells could be used to model human CKD pathology. In patients with injured kidneys, KIM-1 is strongly overexpressed and serves as a negative prognostic marker. Mice overexpressing Kim-1 in renal epithelial cells developed interstitial inflammation followed by progressive fibrotic renal disease, cardiac remodeling and malfunction. In a mouse model of renal fibrosis caused by unilateral ureteral obstruction, mice expressing a mutant form of Kim-1 did not develop renal fibroids, whereas mice with normal Kim-1 did. Next steps include using the model in preclinical studies focused on preventing loss of glomerular filtration rates and secondary complications.

SciBX 6(38); doi:10.1038/scibx.2013.1080
Published online Oct. 3, 2013

Patent applications filed; available for licensing

Humphreys, B.D. et al. J. Clin. Invest.; published online Aug. 27, 2013;
doi:10.1172/JCI45361
Contact: Benjamin D. Humphreys, Brigham and Women's Hospital, Boston, Mass.
e-mail:
bhumphreys@partners.org