Thursday, October 3, 2013
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Mice overexpressing kidney injury molecule 1
(Kim-1) to model chronic
kidney disease (CKD)
Mice that chronically
overexpress Kim-1 in renal epithelial cells could be used to model
human CKD pathology. In patients with injured kidneys, KIM-1 is
strongly overexpressed and serves as a negative prognostic marker. Mice
overexpressing Kim-1 in renal epithelial cells developed interstitial
inflammation followed by progressive fibrotic renal disease, cardiac
remodeling and malfunction. In a mouse model of renal fibrosis caused by
unilateral ureteral obstruction, mice expressing a mutant form of Kim-1
did not develop renal fibroids, whereas mice with normal Kim-1 did. Next
steps include using the model in preclinical studies focused on preventing
loss of glomerular filtration rates and secondary complications.
Published online Oct. 3, 2013
Patent applications filed;
available for licensing
Humphreys, B.D. et al.
J. Clin. Invest.; published online Aug. 27, 2013;
Contact: Benjamin D. Humphreys, Brigham and Women's
Hospital, Boston, Mass.
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