Thursday, October 3, 2013
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Locus-specific control of
histone modification using transcription activator-like (TAL) effector repeat
TAL effector repeats linked
enzymes could enable locus-specific chromatin modification and inform
epigenetic drug development. TAL effector repeats targeting specific DNA
sequences were linked to lysine-specific histone demethylase 1
(KDM1A; LSD1), which enabled
locus-specific binding and reduction in levels of H3K4me2 and H3K27
acetylation, whereas a TAL effector alone did not. Next steps include using
this approach to better understand how compounds that inhibit
chromatin-modifying proteins function in normal and cancerous cells and to
guide their development and identify potential biomarkers.
Published online Oct. 3, 2013
Patent application filed;
available for licensing
Mendenhall, E.M. et al.
Nat. Biotechnol.; published online Sept. 8, 2013;
Contact: Bradley E. Bernstein, Massachusetts General Hospital,
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