Thursday, October 3, 2013
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Interferon regulatory factor 4 (Irf4)-deficient mouse
models of chronic lymphocytic leukemia (CLL)
Irf4-deficient mice could be used to study CLL
pathogenesis. In the New Zealand Black mouse strain, heterozygous deletion of
Irf4 increased the number of animals that developed CLL within 12
months compared with wild-type Irf4 expression. In a different mouse
strain, animals with homozygous deletion of Irf4 and knock-in of the
IgG heavy chain Vh11 developed CLL with 100%
penetrance within 10 months, whereas Vh11 knock-in models with
heterozygous Irf4 deletion or normal Irf4 expression did not.
Ongoing work includes using the models to elucidate how IRF4
contributes to the development of CLL.
Published online Oct. 3, 2013
Findings from both studies
Ma, S. et al. J. Biol.
Chem.; published online July 29, 2013;
Shukla, V. et al. Blood; published online Aug. 7, 2013;
Contact: Runqing Lu, University of Nebraska Medical Center,
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