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Disease models

Doxycycline-inducible adipocyte labeling system for in vivo adipogenesis monitoring

A doxycycline-inducible adipocyte labeling system in mice could be useful for studying and monitoring adipogenesis. The engineered AdipoChaser mice enabled lineage tracing of white adipose tissues and monitoring of adipogenesis during high-fat diet feeding and cold exposure. The mouse system was able to show differences in the adipogenic potential of epididymal, subcutaneous and gonadal fat deposits. Next steps include using the AdipoChaser mice to monitor additional states of adipogenesis.

SciBX 6(38); doi:10.1038/scibx.2013.1075
Published online Oct. 3, 2013

Unpatented; model available for licensing

Wang, Q.A. et al. Nat. Med.; published online Sept. 1, 2013;
Contact: Philipp E. Scherer, The University of Texas Southwestern Medical Center, Dallas, Texas