Thursday, September 26, 2013
This week in techniques
Publication and contact
Measuring CD8+ T cell tumor infiltration to guide immunotherapy
Studies in mice and in
patient samples suggest measuring CD8+ T cell
infiltration of tumors could help identify patients who will respond to
immunotherapies. In samples from patients with melanoma, CD8+ T cell infiltration correlated with elevated tumor
cell death 1 ligand 1 (CD274
In xenograft mice, CD8+ T cell infiltration led to immune-suppressive Treg
accumulation by driving Treg recruitment and proliferation in the
tumor microenvironment. Next steps include integrating this information into
immunotherapy trials and testing combinations of immunotherapies in
Published online Sept. 26, 2013
Patent and licensing status
Spranger, S. et al. Sci.
Transl. Med.; published online Aug. 28, 2013;
Contact: Thomas F. Gajewski,
The University of Chicago, Chicago, Ill.
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]