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Measuring CD8+ T cell tumor infiltration to guide immunotherapy selection

Studies in mice and in patient samples suggest measuring CD8+ T cell infiltration of tumors could help identify patients who will respond to immunotherapies. In samples from patients with melanoma, CD8+ T cell infiltration correlated with elevated tumor levels of indoleamine 2,3-dioxygenase (INDO; IDO) and programmed cell death 1 ligand 1 (CD274 molecule; PD-L1; B7-H1). In xenograft mice, CD8+ T cell infiltration led to immune-suppressive Treg accumulation by driving Treg recruitment and proliferation in the tumor microenvironment. Next steps include integrating this information into immunotherapy trials and testing combinations of immunotherapies in preclinical models.

SciBX 6(37); doi:10.1038/scibx.2013.1047
Published online Sept. 26, 2013

Patent and licensing status undisclosed

Spranger, S. et al. Sci. Transl. Med.; published online Aug. 28, 2013;
doi:10.1126/scitranslmed.3006504
Contact: Thomas F. Gajewski,
The University of Chicago, Chicago, Ill.
e-mail:
tgajewsk@medicine.bsd.uchicago.edu