Thursday, September 26, 2013
This week in techniques
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Measuring CD8+ T cell tumor infiltration to guide immunotherapy
Studies in mice and in
patient samples suggest measuring CD8+ T cell
infiltration of tumors could help identify patients who will respond to
immunotherapies. In samples from patients with melanoma, CD8+ T cell infiltration correlated with elevated tumor
cell death 1 ligand 1 (CD274
In xenograft mice, CD8+ T cell infiltration led to immune-suppressive Treg
accumulation by driving Treg recruitment and proliferation in the
tumor microenvironment. Next steps include integrating this information into
immunotherapy trials and testing combinations of immunotherapies in
Published online Sept. 26, 2013
Patent and licensing status
Spranger, S. et al. Sci.
Transl. Med.; published online Aug. 28, 2013;
Contact: Thomas F. Gajewski,
The University of Chicago, Chicago, Ill.
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