Thursday, September 19, 2013
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as a viral vaccine adjuvant
Cell culture and mouse
studies suggest cGAMP could be used as an adjuvant for viral vaccines. cGAMP
synthase (cGAS) was recently identified as a
cytosolic DNA sensor that produces cGAMP, which then activates the type I
interferon pathway through the transmembrane protein 173 (STING; TMEM173) adaptor protein.
In cultured, HIV-infected, human monocytes, small hairpin RNA against cGAS or
STING decreased the production of type I interferon compared with control
shRNA. In mice infected with herpes simplex virus (HSV), knocking out cGAS
decreased immune responses and survival compared with no knockout. In mice,
immunization with cGAMP plus ovalbumin increased B and T cell
responses compared with immunization using ovalbumin alone. Next steps could
include testing formulations of HIV or HSV vaccines with cGAMP adjuvants.
Published online Sept. 19, 2013
Patent applications filed;
licensing status undisclosed
Gao, D. et al. Science;
published online Aug. 8, 2013;
Li, X.-D. et al. Science; published online Aug. 29, 2013;
Contact: Zhijian J. Chen, The University of Texas
Southwestern Medical Center, Dallas, Texas
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