Thursday, September 19, 2013
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Transgenic scavenger receptor class B member 2
(SCARB2) mice to model
enterovirus 71 (EV71) neuropathogenesis
Transgenic mice that
express human SCARB2 could be useful for studying the neuropathogenesis of
EV71 infection and could help identify new treatments and vaccines for the
disease. Current mouse models of EV71 infection do not recapitulate disease
neuropathology because the virus fails to infect murine CNS tissues. In
transgenic mice expressing SCARB2, a known receptor for EV71, infection with
EV71 resulted in viral replication in CNS tissue, ataxia, paralysis and
death, recapitulating the neuropathology of EV71 infection in humans. Next
steps could include using the model to evaluate candidate therapies and
vaccines against EV71 infection.
Published online Sept. 19, 2013
Patent and licensing status
Fujii, K. et al. Proc.
Natl. Acad. Sci. USA; published online
Aug. 19, 2013;
Contact: Satoshi Koike, Tokyo Metropolitan Institute of
Medical Science, Tokyo, Japan
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