Thursday, September 19, 2013
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mice with streptozotocin-induced diabetes as models of diabetic nephropathy
Phlorizin pretreatment in
mice with streptozotocin-induced diabetes make them useful as models to help
identify new treatments for diabetic nephropathy. In mice, high doses of
streptozotocin induce diabetes but also cause acute kidney injury (AKI),
which makes the mice unsuitable as models of diabetic nephropathy. In the
kidneys of mice given a high dose of streptozotocin, AKI markers were
associated with downregulation of solute carrier family 2 facilitated glucose
transporter member 2 (Slc2a2; Glut2). In mouse models of
streptozotocin-induced diabetes, pretreatment with the competitive sodium-glucose cotransporter 2
(SGLT2) inhibitor phlorizin
increased Glut2 levels and decreased both renal uptake of streptozotocin and
consequent AKI compared with vehicle pretreatment. Next steps could include
confirming that the mice develop diabetic nephropathy and using them to
evaluate therapeutic candidates.
Published online Sept. 19, 2013
B. et al. J. Biol. Chem.; published online Aug. 11, 2013;
Contact: Jeroen Declercq, Catholic University Leuven, Leuven, Belgium
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