Thursday, September 19, 2013
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Mouse model of psoriasis
using epidermis-selective wntless homolog (WLS; EVI; GPR177) knockout
Mouse and human skin sample
studies suggest knockout of Evi in the mouse epidermis could model
psoriasis. In mice, conditional knockout of the wingless-type
MMTV integration site (Wnt)
cargo receptor Evi in the epidermis caused features of human
psoriasis, including hair loss, skin inflammation and redness and loss of
skin barrier function. Evi knockout in the epidermis also increased
inflammatory cytokine expression in the skin and immune cell infiltration
compared with no knockout. In skin samples from patients with psoriasis, EVI
protein and mRNA expression was lower in psoriatic lesions than in healthy
skin. Next steps could include using the model to test therapeutics.
Published online Sept. 19, 2013
Patent and licensing status
Augustin, I. et al. J.
Exp. Med.; published online Aug. 5, 2013;
Contact: Michael Boutros, German Cancer Research Center, Heidelberg,
Contact: Iris Augustin, same affiliation as above
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