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Disease models

Mouse model of psoriasis using epidermis-selective wntless homolog (WLS; EVI; GPR177) knockout

Mouse and human skin sample studies suggest knockout of Evi in the mouse epidermis could model psoriasis. In mice, conditional knockout of the wingless-type MMTV integration site (Wnt) cargo receptor Evi in the epidermis caused features of human psoriasis, including hair loss, skin inflammation and redness and loss of skin barrier function. Evi knockout in the epidermis also increased inflammatory cytokine expression in the skin and immune cell infiltration compared with no knockout. In skin samples from patients with psoriasis, EVI protein and mRNA expression was lower in psoriatic lesions than in healthy skin. Next steps could include using the model to test therapeutics.

SciBX 6(36); doi:10.1038/scibx.2013.1008
Published online Sept. 19, 2013

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Augustin, I. et al. J. Exp. Med.; published online Aug. 5, 2013;
Contact: Michael Boutros, German Cancer Research Center, Heidelberg, Germany
Contact: Iris Augustin, same affiliation as above