Thursday, September 12, 2013
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conjugate vaccines to prevent bacterial infection
In vitro and mouse studies suggest modular, noncovalent
conjugate vaccines could be useful for preventing bacterial infections. A
pneumococcal peptide antigen fused to the biotin-binding
was co-incubated with a biotinylated bacterial polysaccharide to form a
tightly associated noncovalent complex. Mice vaccinated with the complex had
better B and T cell responses and survival than controls inoculated with
conventional pneumococcal conjugate vaccine. Next steps include developing a
multivalent version of the vaccine targeting other bacterial antigens.
GlaxoSmithKline plc's Synflorix
Inc.'s Prevnar and
pneumococcal conjugate vaccines are marketed to prevent pneumococcal disease.
Published online Sept. 12, 2013
Method of construction of
noncovalent conjugate vaccines subject to a pending patent; available for
Zhang, F. et al. Proc.
Natl. Acad. Sci. USA; published online July 29, 2013;
Contact: Richard Malley, Boston Children's Hospital, Boston,
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