Thursday, September 5, 2013
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2´-O-methyltransferase-deficient, live, attenuated dengue virus vaccine
2´-O-methyltransferase-deficient dengue virus
could be used to develop live, attenuated vaccines against the infection. In
mice and nonhuman primates, dengue virus serotypes 1 and 2
with loss-of-function mutations in 2´-O-methyltransferase were attenuated but
still induced a protective immune response, including the production of
neutralizing antibodies. In mice and nonhuman primates, vaccination with an
attenuated dengue strain protected the animals from a subsequent challenge
with a virulent strain. Next steps include evaluating the 2´-O-methyltransferase deficiency in dengue
virus serotypes 3 and 4 and then developing a vaccine candidate that could
protect against all four dengue virus serotypes.
Published online Sept. 5, 2013
Patent application filed;
available for licensing from the Agency
for Science, Technology and Research (A*STAR)
Züst, R. et al. PLoS Pathog.;
published online Aug. 1, 2013;
Contact: Katja Fink, Agency for Science, Technology and
Research (A*STAR), Singapore
Contact: Pei-Yong Shi, Novartis Institute for Tropical
Contact: Cheng-Feng Qin, Beijing Institute of Microbiology
& Epidemiology, Beijing, China
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