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Disease models

Mouse model of atopic dermatitis-like inflammation

A transgenic mouse model of atopic dermatitis could be useful for studying disease pathogenesis and identifying new treatments for the condition. In the model, mice were engineered to overexpress Il-33 (Nf-hev) in the skin and developed spontaneous itchy dermatitis at 6-8 weeks of age. The mice developed skin lesions that recapitulated the markers of atopic dermatitis in humans, including increased mast cell, histamine and IgE levels, whereas skin from wild-type controls did not. In the mouse model, a histamine receptor antagonist decreased scratching behaviors compared with no treatment. Next steps could include using the model to evaluate therapeutic candidates for atopic dermatitis.

SciBX 6(34); doi:10.1038/scibx.2013.939
Published online Sept. 5, 2013

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Imai, Y. et al. Proc. Natl. Acad. Sci. USA; published online Aug. 5, 2013;
Contact: Kiyofumi Yamanishi,
Hyogo College of Medicine, Nishinomiya, Japan
Contact: Kenji Nakanishi,
same affiliation as above