Thursday, September 5, 2013
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Mouse model of atopic
transgenic mouse model of atopic dermatitis could be useful for studying
disease pathogenesis and identifying new treatments for the condition. In the
model, mice were engineered to overexpress Il-33
in the skin and developed spontaneous itchy dermatitis at 6-8 weeks of age.
The mice developed skin lesions that recapitulated the markers of atopic
dermatitis in humans, including increased mast cell, histamine and IgE
levels, whereas skin from wild-type controls did not. In the mouse model, a
histamine receptor antagonist decreased scratching behaviors compared with no
treatment. Next steps could include using the model to evaluate therapeutic
candidates for atopic dermatitis.
Published online Sept. 5, 2013
Patent and licensing status
Imai, Y. et al. Proc.
Natl. Acad. Sci. USA; published online Aug. 5, 2013;
Contact: Kiyofumi Yamanishi,
Hyogo College of Medicine, Nishinomiya, Japan
Contact: Kenji Nakanishi,
same affiliation as above
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