Thursday, September 5, 2013
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Biosynthesis of GE2270
and derivatives in Nonomuraea
of GE2270 in a strain of Nonomuraea bacteria could lead to the
development of improved methods for synthesizing the thiopetide macrocycle
and creating derivatives. GE2270 and its derivatives have potent activity
against Gram-positive bacteria, but the bacteria that produces it, Planobispora
rosea, is not amenable to genetic manipulation. The P. rosea gene
cluster responsible for GE2270 synthesis was expressed in a strain of Nonomuraea
that is amenable to genetic manipulation. In the transgenic Nonomuraea
strain, manipulation of the GE2270 gene cluster resulted in the generation of
four fully cyclized GE2270 variants. Next steps could include generating
additional GE2270 variants and optimizing their potency and pharmacokinetic
Published online Sept. 5, 2013
Patent application filed;
licensing status unavailable
Tocchetti, A. et al.
Chem. Biol.; published online Aug. 8, 2013;
Contact: Margherita Sosio, Naicons scarl, Milan, Italy
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