This week in techniques



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Disease models

Mouse model of fibroblast growth factor 9 (Fgf9; Gaf)-driven lung cancer

Transgenic mice with inducible expression of Fgf9 in lung epithelium could be useful as a model to help identify new treatments for lung cancer. In the mouse model, doxycycline-induced expression of Fgf9 resulted in the formation of papillary adenocarcinomas in the lung within eight days of induction. In this model, knocking out fibroblast growth factor receptor 3 (Fgfr3; Cd333) prevented the formation of lung adenocarcinomas. Next steps include using the model to study signaling pathways activated by FGFR signaling and further define the events involved in lung cancer oncogenesis and metastasis.

SciBX 6(33); doi:10.1038/scibx.2013.906
Published online Aug. 29, 2013

Model unpatented; available for licensing

Yin, Y. et al. Cancer Res.; published online July 18, 2013;
Contact: David M. Ornitz, Washington University in St. Louis, St. Louis, Mo.