This week in techniques



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Drug platforms

Small molecule cocktail for generating pluripotent stem cells from somatic cells

A cocktail of small molecules could be used to reprogram fibroblasts into pluripotent stem cells. In mouse embryonic fibroblasts, a cocktail of 7 small molecules reprogrammed up to 0.2% of the somatic cells into cells with an embryonic stem cell-like morphology. In mice, injected reprogrammed cells differentiated into tissues from all three germ layers. In mouse eight-cell embryos and blastocysts, injected reprogrammed cells integrated into all three germ layers and could be transmitted to subsequent generations. Next steps include developing a similar small molecule cocktail for use with human somatic cells.

SciBX 6(32); doi:10.1038/scibx.2013.877
Published online Aug. 22, 2013

Patent application filed; available for licensing from the Peking University Office of Science and Technology Development

Hou, P. et al. Science; published online July 18, 2013;
Contact: Hongkui Deng, Peking University, Beijing, China

Contact: Yang Zhao, same affiliation as above