This week in techniques

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Disease models

Neurobeachin-like 2 (Nbeal2) knockout mouse model of gray platelet syndrome

Mice lacking Nbeal2 could be used as models of gray platelet syndrome and could help develop new treatments for the condition. Gray platelet syndrome is an inherited disorder caused by mutations in NBEAL2. Mice deficient in Nbeal2 showed impairments in megakaryocyte development and had defects in platelet function including decreased adhesion, aggregation and coagulation activity compared with platelets from wild-type mice. Next steps include using the mouse model to better understand the molecular function of Nbeal2.

SciBX 6(32); doi:10.1038/scibx.2013.873
Published online Aug. 22, 2013

Unpatented; licensing status not applicable for findings from both studies

Kahr, W.H.A. et al. Blood; published online July 16, 2013;
doi:10.1182/blood-2013-04-499491
Contact: Walter H.A. Kahr, University of Toronto, Toronto, Ontario, Canada
e-mail:
walter.kahr@sickkids.ca


Deppermann, C. et al. J. Clin. Invest.; published online July 1, 2013;
doi:10.1172/JCI69210
Contact: David Stegner, University Hospital Wuerzburg and the Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wuerzburg, Wuerzburg, Germany
e-mail:
stegner@virchow.uni-wuerzburg.de