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Synthetic vascular networks derived from human pluripotent stem cells

In vitro and mouse studies suggest patient-specific synthetic vascular networks could be used for vascular regeneration. In vitro, early vasculature cells derived from human pluripotent stem cells matured into endothelial cells and pericytes and organized into a vascular network on a synthetic matrix. In mice, subcutaneously implanted synthetic vascular networks integrated with the existing vasculature and carried blood. Next steps include testing the strategy in large animal models.

SciBX 6(31); doi:10.1038/scibx.2013.845
Published online Aug. 15, 2013

Patent application filed and optioned to an undisclosed startup; unavailable for licensing

Kusuma, S. et al. Proc. Natl. Acad. Sci. USA; published online July 15, 2013;
Contact: Sharon Gerecht, Johns Hopkins University, Baltimore, Md.