Thursday, August 15, 2013
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transplantable, vascularized liver buds from induced pluripotent stem (iPS)
Human vascularized liver
buds grown in culture could be used to regenerate human livers and model
liver disease. Liver endoderm cells generated from human iPS cells were
co-cultured with human endothelial cells and mesenchymal stem cells to form
vascularized liver buds. In mice, implanted liver buds integrated with the
host vasculature, matured and performed human liver-specific metabolic
reactions. In mice with chemically induced liver failure, transplanted liver
buds prolonged survival compared with transplanted hepatocytes. Next steps
include scaling up the process to establish larger tissue segments and
testing functionality in larger animal models.
Published online Aug. 15, 2013
Patent application filed;
available for licensing through Yokohama City University
Takebe, T. et al. Nature;
published online July 3, 2013;
Contact: Takanori Takebe, Yokohoma City University,
Contact: Hideki Taniguchi, same affiliation as above
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