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Direct reprogramming of fibroblasts into induced hepatic stem cells (iHSCs) for liver regeneration

iHSCs derived directly from fibroblasts could help treat liver diseases. In culture, iHSCs generated from mouse embryonic fibroblasts by expression of the HNF1 homeobox B (Hnf1b) and forkhead box A3
(Foxa3) transcription factors were capable of self-renewal and differentiation into both hepatocytes and cholangiocytes. In a mouse model of liver failure, intrasplenic transplantation of the iHSCs improved liver function and survival compared with transplantation of mouse embryonic fibroblasts. Next steps could include translating the method to human cells.

SciBX 6(31); doi:10.1038/scibx.2013.842
Published online Aug. 15, 2013

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 Yu, B. et al. Cell Stem Cell; published online July 18, 2013;


Contact: Yi-Ping Hu, Second Military Medical University, Shanghai, China


Contact: Xin Wang, Inner Mongolia University, Huhhot, China