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Disease models

Mouse model of neonatal intracranial hemorrhage

A mouse model of neonatal intracranial hemorrhage could be useful for developing therapies for the condition. In mice engineered to conditionally express VEGF in the brain, induction of VEGF during late embryonic development led to germinal matrix hemorrhage and intraventricular hemorrhage, two common forms of neonatal hemorrhage. In the mouse model, glucocorticoid treatment decreased VEGF-induced hemorrhage compared with no treatment. Next steps include exploring the therapeutic potential of antagonizing downstream effectors of VEGF signaling.

SciBX 6(31); doi:10.1038/scibx.2013.839
Published online Aug. 15, 2013

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Yang, D. et al. Sci. Transl. Med.; published online July 10, 2013;
Contact: Chia-Yi Kuan, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio