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Disease models

Dominant negative-disrupted in schizophrenia 1 (DISC1) mouse models of prefrontal cortex dysfunction

Mice expressing a dominant negative form of DISC1 (DN-DISC1) could help model cognitive disorders. In models of adaptive behavior, DN-DISC1 mice showed decreased ability to modify responses or alter expectations compared with wild-type mice. In behavioral motivation models, DN-DISC1 mice showed decreased effort for reward and decreased interaction with unknown mice compared with wild-type mice. Next steps include using DN-DISC1 mice in discovery programs for neuropsychiatric and neurological disorders.

SciBX 6(31); doi:10.1038/scibx.2013.836
Published online Aug. 15, 2013

Unpatented; licensing status not applicable

Johnson, A.W. et al. Proc. Natl. Acad. Sci. USA; published online July 9, 2013;
Contact: Michela Gallagher, The Johns Hopkins University, Baltimore, Md.
Contact: Akira Sawa, affiliation as above