Thursday, August 8, 2013
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variants of a-synuclein (SNCA)
to classify neurodegenerative diseases
variants of SNCA could be useful as biomarkers for distinguishing between
subtypes of neurodegenerative diseases including Parkinson's disease (PD). In
cultured mouse neurons, expression of two different synthetic conformational
variants of human SNCA drove distinct patterns of SNCA and microtubule-associated
inclusion formation. In brain tissue samples from five patients with PD and
dementia, two showed expression of a single SNCA conformation, whereas the
other three showed expression of two SNCA conformations. Next steps include
studies to determine why different SNCA variants produce distinct disease
pathologies and to understand the significance of such differences.
Published online Aug. 8, 2013
Patent application filed
covering antibodies against the different SNCA variants; unavailable for
Guo, J.L. et al. Cell;
published online July 3, 2013;
Contact: Virginia M.Y. Lee, University of Pennsylvania
School of Medicine, Philadelphia, Pa.
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