Thursday, August 8, 2013
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Glucose chemical exchange
saturation transfer (glucoCEST) to image enhanced glucose uptake in tumor
Mouse studies suggest the
glucoCEST imaging method could help diagnose cancer in a noninvasive manner
without needing radioactive tracers. GlucoCEST is an MRI method that can
detect uptake of unlabeled glucose without radioactive tracers because of the
magnetic effect of the transfer of hydroxyl protons from glucose to water
during MRI. In two mouse models with subcutaneous colorectal cancer xenografts,
glucoCEST detected higher glucose accumulation in tumor tissues than in
muscle tissues and differentiated between tumors with varied metabolic
profiles. Next steps could include testing the method in additional cancer
Published online Aug. 8, 2013
Patent and licensing status
Walker-Samuel, S. et al.
Nat. Med.; published online July 7, 2013;
Contact: Simon Walker-Samuel, University College London,
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