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Galectin-1 (LGALS1) as a prognostic marker of early onset preeclampsia

Monitoring levels of serum LGALS1 could help predict risk of severe preeclampsia. In 24 pregnant women, circulating levels of LGALS1 were lower during the second trimester in women who developed preeclampsia than levels in women who did not. In pregnant mice, Lgals1 knockout or an LGALS1 inhibitor administered in early pregnancy increased blood pressure, proteinuria and other symptoms seen in human preeclampsia compared with no knockout or no treatment, respectively. Ongoing work includes validating serum LGALS1 as a prognostic marker of preeclampsia in a large cohort of pregnant women.

SciBX 6(29); doi:10.1038/scibx.2013.777
Published online Aug. 1, 2013

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Freitag, N. et al. Proc. Natl. Acad. Sci. USA; published online June 24, 2013;
Contact: Sandra M. Blois, Charité-University Hospital Berlin, Berlin, Germany