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Self-assembling, osteogenic, polymer-based coating to prevent joint implant failure

Rodent studies suggest a self-assembling, osteogenic, polymer-based coating could help prevent joint implant failure. The multilayer polymer coating is less than 2 mm thick and consists of a permanent osteoconductive hydroxyapatite base layer underneath hydrolytically degradable osteoinductive poly(b-amino ester) layers that slowly release bone morphogenetic protein 2 (BMP2). In a rat model for implant integration, implants that used the multilayer polymer coating showed better integration with host bone and greater tensile strength at the bone-implant interface than implants stabilized with conventional bone cement. In the model, implants with the polymer coating showed long-term stable fixation to host bone and no fracturing at the bone-implant interface as measured out to 18 months. Next steps include evaluating implants that use the coating in large animal models.

SciBX 6(29); doi:10.1038/scibx.2013.775
Published online Aug. 1, 2013

Patent application filed; available for licensing

Shah, N.J. et al. Sci. Transl. Med.; published online June 26, 2013;
Contact: Paula T. Hammond, Massachusetts Institute of Technology, Cambridge, Mass.