Thursday, August 1, 2013
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osteogenic, polymer-based coating to prevent joint implant failure
Rodent studies suggest a
self-assembling, osteogenic, polymer-based coating could help prevent joint
implant failure. The multilayer polymer coating is less than 2 mm
thick and consists of a permanent osteoconductive hydroxyapatite base layer
underneath hydrolytically degradable osteoinductive poly(b-amino
ester) layers that slowly release bone morphogenetic protein 2
(BMP2). In a rat model for
implant integration, implants that used the multilayer polymer coating showed
better integration with host bone and greater tensile strength at the
bone-implant interface than implants stabilized with conventional bone
cement. In the model, implants with the polymer coating showed long-term
stable fixation to host bone and no fracturing at the bone-implant interface
as measured out to 18 months. Next steps include evaluating implants that use
the coating in large animal models.
Published online Aug. 1, 2013
Patent application filed;
available for licensing
Shah, N.J. et al. Sci.
Transl. Med.; published online June 26, 2013;
Contact: Paula T. Hammond, Massachusetts Institute of
Technology, Cambridge, Mass.
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