Thursday, August 1, 2013
This week in
Publication and contact
osteogenic, polymer-based coating to prevent joint implant failure
Rodent studies suggest a
self-assembling, osteogenic, polymer-based coating could help prevent joint
implant failure. The multilayer polymer coating is less than 2 mm
thick and consists of a permanent osteoconductive hydroxyapatite base layer
underneath hydrolytically degradable osteoinductive poly(b-amino
ester) layers that slowly release bone morphogenetic protein 2
(BMP2). In a rat model for
implant integration, implants that used the multilayer polymer coating showed
better integration with host bone and greater tensile strength at the
bone-implant interface than implants stabilized with conventional bone
cement. In the model, implants with the polymer coating showed long-term
stable fixation to host bone and no fracturing at the bone-implant interface
as measured out to 18 months. Next steps include evaluating implants that use
the coating in large animal models.
Published online Aug. 1, 2013
Patent application filed;
available for licensing
Shah, N.J. et al. Sci.
Transl. Med.; published online June 26, 2013;
Contact: Paula T. Hammond, Massachusetts Institute of
Technology, Cambridge, Mass.
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]