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Near-infrared fluorescent proteins (iRFPs) that allow multicolor, in vivo imaging

In vitro and mouse studies identified four iRFPs that could be used for noninvasive, multicolor imaging in animals. In HeLa cells and in mice, the new iRFPs produced distinct colors and had sufficient brightness to allow long-term imaging. In mice, two iRFPs could be used simultaneously to image and differentiate between tissues at different depths. Next steps could include testing the agents in additional models and specific processes.

SciBX 6(28); doi:10.1038/scibx.2013.742
Published online July 25, 2013

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Shcherbakova, D.M. & Verkhusha, V.V.
Nat. Methods; published online June 16, 2013;
Contact: Vladislav V. Verkhusha, Albert Einstein College of Medicine of Yeshiva University, Bronx, N.Y.