Thursday, July 25, 2013
Publication and contact
Crystal structure of variable
lymphocyte receptor (VLR) VLRB.aGPA.23
with a tumor-associated glycan antigen
The crystal structure of
VLR bound to a tumor-associated glycan antigen could be useful for designing
tumor-targeting VLRs for therapeutic and diagnostic applications. VLRs are
adaptive immunity proteins from jawless vertebrates that bind glycans with
selectivity comparable to that of antibodies. Crystal structure and
thermodynamic studies showed that VLRB.aGPA.23 binds the tumor-associated Thomsen-Friedenreich
with four tryptophan residues that create a hydrophobic cage around the
target disaccharide. Next steps include developing VLRB.aGPA.23 as a
diagnostic reagent and determining its targets for therapeutic applications.
Published online July 25, 2013
Patents issued and pending
covering VLR composition of matter and methods for making and using the VLRs;
available for licensing
Luo, M. et al. J. Biol.
published online June 19, 2013;
Contact: Roy A. Mariuzza, Institute for Bioscience and
Biotechnology Research at the University of Maryland, Rockville, Md.
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]