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IL-12-expressing oncolytic herpes virus to treat glioblastoma

Mouse studies identified an oncolytic virus expressing IL-12 that could help treat glioblastoma. In a mouse model for glioma stem cell-induced glioblastoma, an oncolytic herpes virus expressing a mouse Il-12 transgene inhibited tumor growth and increased survival compared with a virus expressing no transgene or saline. In this model, the virus expressing
Il-12 also inhibited angiogenesis and induced a T cell-mediated immune response against the cancer cells. Next steps include creating an oncolytic virus that could be evaluated in clinical trials.

SciBX 6(27); doi:10.1038/scibx.2013.706
Published online July 18, 2013

Patented by Georgetown University and Massachusetts General Hospital; licensed to Catherex Inc.; Massachusetts General Hospital patents available for licensing

Cheema, T.A. et al. Proc. Natl. Acad. Sci. USA; published online
June 10, 2013;
Contact: Samuel D. Rabkin, Massachusetts General Hospital and Harvard Medical School,
Boston, Mass.