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Drug delivery

Tissue-specific drug delivery with antibody-coated, polymer, rod-shaped nanoparticles (nanorods)

Nanorods could help deliver drugs to target tissues with higher specificity than spherical nanoparticles. In cultured rat brain endothelial cells and in a microfluidic model for the vascular system lined with such cells, nanorods coated with antibody against mouse intercellular adhesion molecule-1 (Icam-1; Cd54) showed greater cellular uptake and adhesion than spherical nanoparticles coated with the same antibody. In normal mice, nanorods coated with antibodies against Icam-1 or mouse transferrin receptor showed higher accumulation in lungs and brain compared with spherical nanoparticles coated with the same respective antibodies. Next steps could include testing drug-loaded nanorods in animal models for cancer.

SciBX 6(27); doi:10.1038/scibx.2013.703
Published online July 18, 2013

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Kolhar, P. et al. Proc. Natl. Acad. Sci. USA; published online June 10, 2013;
Contact: Samir Mitragotri, University of California, Santa Barbara, Calif.
Contact: Erkki Ruoslahti, Sanford-Burnham Medical Research Institute, La Jolla, Calif.