This week in techniques



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Assays & screens

Fluorescence-based bilirubin assay

A fluorescent, bilirubin-binding protein, called UnaG, from the Japanese eel could be useful for a new bilirubin diagnostic assay. UnaG is an apoprotein that binds unconjugated bilirubin with high affinity and selectivity and that fluoresces upon binding. In both serum and whole blood, UnaG-based quantitation of unconjugated bilirubin was shown to be independent of conjugated bilirubin. Next steps include development of a low-cost fluorescence detector for use with the assay.

SciBX 6(27); doi:10.1038/scibx.2013.697
Published online July 18, 2013

Patented by RIKEN; available for licensing

Kumagai, A. et al. Cell; published online June 13, 2013;
Contact: Atsushi Miyawaki, RIKEN Brain Science Institute, Saitama, Japan