Thursday, July 11, 2013
Publication and contact
antigen display screening platform
A mammalian platform for
surface antigen display could be used to screen for and discover therapeutic
antibodies. A difficult step for in vitro antibody discovery is the
cloning of candidates discovered via bacterial display systems into mammalian
cell expression systems. In the current platform, human embryonic kidney 293
(HEK293) cells were transfected with a vector that caused them to display a
protein on their surface and secrete it into culture media. The vector also
was used to create HEK293 cell lines that displayed and secreted antibodies,
antibody fragments and antibody fusion proteins. AnaptysBio
Inc. has integrated this system into its SHM-XEL
human antibody generation platform, and next steps include using the platform
to develop therapeutic and diagnostic antibodies.
Published online July 11, 2013
Covered by issued and
pending patents; antibody discovery platform already partnered with multiple
companies and government agencies
Horlick, R.A. et al. J.
Biol. Chem.; published online May 20, 2013;
Contact: Robert A. Horlick, AnaptysBio Inc., San Diego,
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