Thursday, July 11, 2013
Publication and contact
Structural analysis of
bovine complementarity-determining regions (CDRs) could guide the development
of new antibody libraries. Cows have distinct immunoglobulin features
including long CDRs and limited variable regions, and the molecular basis of
their antibody diversity is not well understood. A series of computational
and structural experiments demonstrated that these long CDRs can form
numerous disulfide bonds that generate structural diversity through folding
into unusual stalk- or knob-shaped structures. Next steps include
constructing libraries of cow antibodies to identify hits against potentially
LLC, which coauthored the study and was cofounded by Vaughn
Smider, is developing antibody screening platforms based on the technology.
Published online July 11, 2013
Patent applications filed;
unavailable for licensing
Wang, F. et al. Cell;
published online June 6, 2013;
Contact: Vaughn V. Smider, The Scripps Research Institute,
La Jolla, Calif.
Contact: Ian A. Wilson, same affiliation as above
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]