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Drug platforms

Cow-derived antibody scaffolds

Structural analysis of bovine complementarity-determining regions (CDRs) could guide the development of new antibody libraries. Cows have distinct immunoglobulin features including long CDRs and limited variable regions, and the molecular basis of their antibody diversity is not well understood. A series of computational and structural experiments demonstrated that these long CDRs can form numerous disulfide bonds that generate structural diversity through folding into unusual stalk- or knob-shaped structures. Next steps include constructing libraries of cow antibodies to identify hits against potentially difficult targets.
Fabrus LLC, which coauthored the study and was cofounded by Vaughn Smider, is developing antibody screening platforms based on the technology.

SciBX 6(26); doi:10.1038/scibx.2013.671
Published online July 11, 2013

Patent applications filed; unavailable for licensing

Wang, F. et al. Cell; published online June 6, 2013;
Contact: Vaughn V. Smider, The Scripps Research Institute, La Jolla, Calif.

Contact: Ian A. Wilson, same affiliation as above