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Functionalized, methacrylated hyaluronic acid hydrogels for cartilage repair

Methacrylated hyaluronic acid hydrogels functionalized with N-cadherin mimetic peptides could be useful for cartilage repair. An in vitro cartilage formation assay using methacrylated hyaluronic acid hydrogels containing N-cadherin mimetic peptides increased human mesenchymal stem cell (MSC)-mediated chondrogenesis compared with the same hydrogel containing scrambled peptides. In immunodeficient mice, implantation of human MSC-seeded hydrogel disks containing N-cadherin mimetic peptides increased chondrogenesis compared with implantation of hydrogel disks containing scrambled peptides. Next steps include improving the cellular response to the hydrogel and analyzing the system in a large animal model.

SciBX 6(25); doi:10.1038/scibx.2013.638
Published online June 27, 2013

Unpatented; licensing status not applicable

Bian, L. et al. Proc. Natl. Acad. Sci. USA; published online June 3, 2013;
doi:10.1073/pnas.1214100110
Contact: Jason A. Burdick, University of Pennsylvania, Philadelphia, Pa.
e-mail:
burdick2@seas.upenn.edu