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Serine racemase (Srr) knockout mouse model for schizophrenia

Srr knockout mice could be useful for identifying and evaluating therapies to treat schizophrenia. Srr is needed to make the NMDAR coagonist d-serine, which is known to be at low levels in patients with schizophrenia. Srr knockout mice had less brain d-serine than wild-type mice and showed schizophrenia-associated electrophysiological, biochemical and behavioral markers. Peripheral treatment with d-serine increased d-serine levels in the mouse brains compared with vehicle treatment and corrected schizophrenia-like phenotypes. Next steps could include testing other NMDAR modulators in Srr knockout mice.

SciBX 6(25); doi:10.1038/scibx.2013.637
Published online June 27, 2013

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Balu, D.T. et al. Proc. Natl. Acad. Sci. USA; published online May 31, 2013;
doi:10.1073/pnas.1304308110
Contact: Joseph T. Coyle, Harvard Medical School, Boston, Mass.
e-mail:
joseph_coyle@hms.harvard.edu