Thursday, June 20, 2013
Publication and contact
Nuclear localization status
of nuclear factor (erythroid-derived 2)-like 2
(NFE2L2; NRF2) to distinguish
essential thrombocythemia (ET) and primary myelofibrosis (MF)
The nuclear localization
status of NRF2 could help differentiate between the myeloproliferative
disorders ET and primary MF. In patient biopsies, anti-NRF2 antibodies showed
less than 17% nuclear NRF2 localization in erythroid cells from ET samples
and greater than 27% nuclear NRF2 localization in erythroid cells from
primary MF samples. Computational analysis of the biopsy data sets using NRF2
nuclear localization-based cutoff values distinguished between ET and primary
MF with 92% accuracy. Next steps could include testing the method in patients
with unclassifiable myeloproliferative disorders.
Published online June 20, 2013
Patent and licensing status
Aumann, K. et al. Blood;
published online May 13, 2013;
Contact: Heike L. Pahl, University Medical Center Freiburg,
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]