Thursday, June 20, 2013
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Nuclear localization status
of nuclear factor (erythroid-derived 2)-like 2
(NFE2L2; NRF2) to distinguish
essential thrombocythemia (ET) and primary myelofibrosis (MF)
The nuclear localization
status of NRF2 could help differentiate between the myeloproliferative
disorders ET and primary MF. In patient biopsies, anti-NRF2 antibodies showed
less than 17% nuclear NRF2 localization in erythroid cells from ET samples
and greater than 27% nuclear NRF2 localization in erythroid cells from
primary MF samples. Computational analysis of the biopsy data sets using NRF2
nuclear localization-based cutoff values distinguished between ET and primary
MF with 92% accuracy. Next steps could include testing the method in patients
with unclassifiable myeloproliferative disorders.
Published online June 20, 2013
Patent and licensing status
Aumann, K. et al. Blood;
published online May 13, 2013;
Contact: Heike L. Pahl, University Medical Center Freiburg,
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