Thursday, June 13, 2013
This week in
Publication and contact
Human embryonic stem cell
(hESC)-derived thymic epithelial cells capable of supporting T cell
A protocol to generate
thymic epithelial cells from hESCs could help restore thymus function and
induce immune tolerance. hESCs were exposed to a series of cocktails
containing multiple growth factors, including modulators of signaling by wingless-type
MMTV integration site (WNT)
morphogenetic protein (BMP),
which converted the cells into thymic epithelial progenitors. In athymic
immunodeficient mice, transplanted progenitor cells differentiated into
thymic epithelial cells that could produce functional T cells. Next steps
include exploring the therapeutic uses of the derived thymic epithelial cells
in mouse models.
Matthias Hebrok and Mark Anderson have cofounded ThyGen
to commercialize the approach.
Published online June 13, 2013
Patent application filed;
exclusively licensed to ThyGen
A.V. et al. Cell Stem Cell; published online May 16, 2013;
Contact: Matthias Hebrok, University of
San Francisco, Calif.
Contact: Mark S. Anderson, same affiliation as above
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]