Thursday, June 6, 2013
Publication and contact
High-density lipoprotein (HDL)-mimicking nanoparticles to detect
vulnerable atherosclerotic plaques
In vitro and rat studies identified synthetic, HDL-mimicking
nanoparticles that could help detect vulnerable atherosclerotic plaques,
which can rupture and cause fatal blood clots. The nanoparticles consist of a
acid) (PLGA) core, cholesteryl oleate and
quantum dots plus a phospholipid bilayer containing an apolipoprotein
mimetic and triphenylphosphonium. The nanoparticles accumulated
in healthy macrophages but not in apoptotic macrophages, which creates a
contrast between the two populations during fluorescence imaging. Apoptotic
macrophages are associated with vulnerable atherosclerotic plaques. In rats,
the nanoparticles also decreased total cholesterol and triglyceride levels
compared with vehicle, which suggests a potential therapeutic benefit. Next
steps include testing the nanoparticles in animal models for atherosclerosis.
Published online June 6, 2013
Patented; available for
Marrache, S. & Dhar, S.
Proc. Natl. Acad. Sci. USA; published online May 13, 2013;
Contact: Shanta Dhar, The University of Georgia, Athens, Ga.
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]