Thursday, May 23, 2013
Publication and contact
Classification system for
In vitro studies were used to develop a classification
system for endometrial cancers that could help guide treatment regimens for
patients after initial therapy. Endometrial cancers are traditionally divided
into the endometrioid and serous subtypes, with favorable and poor prognoses,
respectively. In 373 samples from patients who have endometrial carcinoma,
genome, proteome and transcriptome analyses were used to subdivide the
cancers into four categories based on high or low levels of somatic copy
number variants (CNVs), mutation status of DNA-directed
DNA polymerase e (POLE)
and microsatellite instability. Genetic analysis showed that high somatic
CNVs correlated with a poor prognosis independent of subtype classification.
Next steps could include determining whether there is a relationship between
the identified disease subtypes and treatment response.
Published online May 23, 2013
Patent and licensing status
Cancer Genome Atlas
Research Network. Nature; published online May 1, 2013;
Contact: Douglas A. Levine, Memorial Sloan-Kettering Cancer Center, New
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