Thursday, May 23, 2013
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Scaffolds with endothelial
cell cords to promote vascularization of tissue transplants
Mouse studies suggest
scaffolds containing cords made of endothelial cells could help improve
tissue transplant outcomes. Cords that consist of a cylindrical segment of endothelial
cells that surround a collagen core were generated and embedded within a
fibrin scaffold. In mice, fat pad implantation of a scaffold containing the
endothelial cell cords led to greater vascularization of the scaffold than
implantation of a similar scaffold with randomly organized endothelial cells.
In mice, transplantation of scaffolds containing the endothelial cell cords
plus hepatocytes resulted in increased tissue vascularization and hepatocyte
functionality compared with transplantation of scaffolds with randomly
organized endothelial cells or hepatocytes alone. Next steps could include
testing the patterned scaffolds in additional transplantation models.
Published online May 23, 2013
Patent application filed;
licensed to an undisclosed company
Baranski, J.D. et al.
Proc. Natl. Acad. Sci. USA; published online April 22, 2013;
Contact: Christopher S. Chen, University of Pennsylvania, Philadelphia,
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