Thursday, May 16, 2013
This week in techniques
Publication and contact
Brain metastasis markers in
cell adhesion molecule (EpCAM)-
circulating tumor cells (CTCs)
A protein signature
specific to EpCAM- CTCs could be used for early detection of brain
metastasis in patients with breast cancer. EpCAM- CTCs were
isolated from patients with breast cancer, and a subset of the cells that
growth factor receptor (EGFR),
was used to generate stable cell lines. In immunodeficient mice, injection of
cells taken from such cell lines led to brain metastases in 60%-80% of the
animals, whereas only 0%-20% of those injected with CTCs that did not express
the protein signature had brain metastases. Researchers did not disclose next
steps, which could include confirming the signature in larger patient populations
and determining the therapeutic potential of targeting HPSE, which has
previously been associated with brain metastasis.
Published online May 16, 2013
Patent and licensing status
Zhang, L. et al. Sci.
Transl. Med.; published online April 10, 2013;
Contact: Dario Marchetti, Baylor College of Medicine, Houston,
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