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An aged mouse model for protein tyrosine phosphatase non-receptor type 22 (PTPN22; LYP)-associated autoimmunity

An aged mouse model for LYP-associated autoimmune diseases could be used to identify new treatments for conditions including multiple sclerosis (MS) and rheumatoid arthritis (RA). In mice engineered to express PEP-R619W, the mouse ortholog of a human LYP variant that is associated with autoimmune disease, aged mice developed autoantibodies and features of systemic autoimmunity, whereas young mice did not. In the aged mouse model, the stability of the variant protein was similar to that of wild-type protein, but it was functionally altered and caused increased T and B cell proliferation. Next steps could include using the model to identify new autoimmune disease therapeutics.

SciBX 6(19); doi:10.1038/scibx.2013.474
Published online May 16, 2013

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Dai, X. et al. J. Clin. Invest.; published online April 24, 2013;
doi:10.1172/JCI66963
Contact: David J. Rawlings, Seattle Children's Research Institute, Seattle, Wash.
e-mail:
drawling@u.washington.edu