Thursday, May 9, 2013
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Gene expression signature
as a prostate cancer prognostic
A 32-gene expression
signature could help guide the choice of postoperative treatment for prostate
cancer. Bioinformatic analysis of the expression of 1,536 genes in malignant
prostate tissue isolated from patients with prostate cancer following radical
prostatectomy identified a 32-gene expression signature that correlated with
outcome. The signature was validated in a blinded cohort of 270 patients, in
which it had greater prognostic value than existing clinical markers. Next
steps include looking prospectively to test whether the expression signature
predicts disease progression.
The work was carried out in collaboration with the bioTheranostics Inc.
subsidiary of bioMerieux S.A.
Published online May 9, 2013
Patented; unavailable for
Wu, C.-L. et al. Proc.
Natl. Acad. Sci. USA; published online March 26, 2013;
Contact: W. Scott McDougal, Massachusetts General Hospital,
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