Thursday, May 9, 2013
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CD44, CD47, c-Met proto-oncogene (MET;
HGFR) and epithelial cell adhesion molecule
as a signature for metastasis-initiating circulating tumor cells (CTCs) in
A protein signature
specific to EpCAM+ CTCs associated with brain metastases could be used
for diagnosis of metastatic breast cancer. EpCAM+ CTCs isolated from individuals with progressive
metastatic breast cancer expressed CD44, CD47 and MET. In immunodeficient
mice, injection of that subset of CTCs resulted in metastasis to the bone. In
blood samples from patients with cancer, increased levels of EpCAM+ CTCs expressing CD44, CD47 and MET correlated with
shorter overall survival. Next steps include genetically examing whether MET
and CD47 are essential for survival and function of metastasis-initiating
cells in hormone receptor-positive breast cancers and testing several MET and
CD47 inhibitors on the newly established CTC lines.
Published online May 9, 2013
Patent application pending;
available for licensing
Baccelli, I. et al. Nat.
Biotechnol.; published online April 21, 2013;
Contact: Andreas Trumpp, Heidelberg Institute for Stem Cell
Technology and Experimental Medicine GmbH, Heidelberg, Germany
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