Licensing status

Publication and contact information

Drug platforms

Self-mineralizing viruses for improved efficacy and storage stability

Cell culture and mouse studies suggest self-mineralizing vaccines could have better efficacy and stability than conventional vaccines. Human enterovirus type 71 engineered to express genes that encode calcium- and phosphate-chelating agents formed a self-mineralized calcium phosphate shell when cultured in calcium-enriched medium. In mice, the engineered virus induced almost twofold higher titers of neutralizing antibodies than the native virus. The mineralized virus was stored for 7 days at 37 °C and for 9 days at 26 °C. Next steps include further improving the vaccine's thermal stability.

SciBX 6(18); doi:10.1038/scibx.2013.449
Published online May 9, 2013

Patent application filed; unavailable for licensing

Wang, G. et al. Proc. Natl. Acad. Sci. USA; published online April 15, 2013;
Contact: Cheng-Feng Qin, Beijing Institute of Microbiology and Epidemiology, Beijing, China
Contact: Ruikang Tang, Zhejiang University, Hangzhou, China