Thursday, May 9, 2013
Publication and contact
Gene regulatory network
mapping in late-onset Alzheimer's disease (AD)
A gene regulatory network
map of late-onset AD could help identify and prioritize pathways and
therapeutic targets in the disease. A bioinformatics analysis of gene
expression data from 1,647 postmortem brain tissue samples from patients with
late-onset AD was used to create a gene regulatory network of the condition.
Analysis of the network found that a set of immunity- and microglia-specific
genes had the strongest association with disease pathophysiology. The
analysis also showed that TYRO protein tyrosine kinase binding protein
(TYROBP) is upregulated in
late-onset AD and acts as a key regulator in the network. Next steps include
continuing functional studies in mouse models and in microglia and carrying
out genetic tests to identify modules with effects on brain atrophy and
Published online May 9, 2013
status not applicable
Zhang, B. et al. Cell;
published online April 25, 2013;
Contact: Valur Emilsson, Icelandic Heart Association and
University of Iceland, Kopavogur, Iceland
Contact: Bin Zhang, Icahn School of Medicine at Mount Sinai,
New York, N.Y.
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]