Thursday, May 9, 2013
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Gene regulatory network
mapping in late-onset Alzheimer's disease (AD)
A gene regulatory network
map of late-onset AD could help identify and prioritize pathways and
therapeutic targets in the disease. A bioinformatics analysis of gene
expression data from 1,647 postmortem brain tissue samples from patients with
late-onset AD was used to create a gene regulatory network of the condition.
Analysis of the network found that a set of immunity- and microglia-specific
genes had the strongest association with disease pathophysiology. The
analysis also showed that TYRO protein tyrosine kinase binding protein
(TYROBP) is upregulated in
late-onset AD and acts as a key regulator in the network. Next steps include
continuing functional studies in mouse models and in microglia and carrying
out genetic tests to identify modules with effects on brain atrophy and
Published online May 9, 2013
status not applicable
Zhang, B. et al. Cell;
published online April 25, 2013;
Contact: Valur Emilsson, Icelandic Heart Association and
University of Iceland, Kopavogur, Iceland
Contact: Bin Zhang, Icahn School of Medicine at Mount Sinai,
New York, N.Y.
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