Thursday, May 9, 2013
Publication and contact
computational model for breast cancer progression
A computational model for
breast cancer progression developed through an open innovation challenge
could lead to better prognostic tests for the disease and help guide the
development of future computational models. An online server was used to host
user-submitted computational algorithms for predicting disease progression
based on a dataset containing expression, copy number and clinical data from
about 2,000 breast cancer samples. The winning model predicted progression on
a validation data set of 184 samples with higher accuracy than that of
previously reported prognostic models for breast cancer. Next steps include
studying the biology underlying predictive features of the model and running
additional challenges in other disease areas using this framework.
Oncotype DX from Genomic Health Inc. and MammaPrint from Agendia B.V. are prognostic
gene expression tests marketed for breast cancer (see DREAM team, page 4).
Published online May 9, 2013
Findings unpatented for
both studies; licensing status not applicable
Margolin, A.A. et al.
Sci. Transl. Med.; published online April 17, 2013;
Contact: Stephen H. Friend, Sage Bionetworks, Seattle, Wash.
Contact: Adam A. Margolin, same affiliation as above
Cheng, W.-Y. et al. Sci. Transl. Med.; published online April 17,
Contact: Dimitris Anastassiou, Columbia University, New
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]