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T2 magnetic resonance (T2MR) nanoparticle diagnostic for systemic Candida infection

A T2MR diagnostic method could be used to detect systemic Candida infection in whole blood samples. The T2MR method uses Candida cell lysis, PCR amplification and nanoparticles that can detect the amplified product in whole blood. In whole blood samples taken from healthy donors and then spiked with various species of the Candida fungus, T2MR detection showed a 98% positive agreement and 100% negative agreement with standard blood culture diagnostics. T2MR detected Candida in blinded whole blood samples from patients in about
2 hours, whereas standard blood culture diagnostics took an average of 48 hours. Next steps include clinical testing.

SciBX 6(18); doi:10.1038/scibx.2013.444
Published online May 9, 2013

T2 Biosystems Inc. has 10 U.S. patents and 10 international patents covering the T2MR method; available for partnering

Neely, L.A. et al. Sci. Transl. Med.; published online April 24, 2013;
Contact: Thomas J. Lowery, T2 Biosystems Inc., Lexington, Mass.