Thursday, May 9, 2013
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Assays & screens
T2 magnetic resonance
(T2MR) nanoparticle diagnostic for systemic Candida infection
A T2MR diagnostic method
could be used to detect systemic Candida infection in whole blood
samples. The T2MR method uses Candida cell lysis, PCR amplification
and nanoparticles that can detect the amplified product in whole blood. In
whole blood samples taken from healthy donors and then spiked with various
species of the Candida fungus, T2MR detection showed a 98% positive
agreement and 100% negative agreement with standard blood culture
diagnostics. T2MR detected Candida in blinded whole blood samples from
patients in about
2 hours, whereas standard blood culture diagnostics took an average of 48
hours. Next steps include clinical testing.
Published online May 9, 2013
T2 Biosystems Inc. has 10 U.S. patents and 10 international patents
covering the T2MR method; available for partnering
Neely, L.A. et al. Sci.
Transl. Med.; published online April 24, 2013;
Contact: Thomas J. Lowery, T2 Biosystems Inc., Lexington,
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