Thursday, May 2, 2013
This week in techniques
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Functional MRI (fMRI) to
and human studies suggest fMRI could be useful for detecting the onset of
psychosis. In patients with a history of psychosis, fMRI at the onset of psychotic
episodes showed decreased hippocampus size but increased hippocampal activity
compared with that of nonpsychotic controls. In an fMRI study of mice with
acute ketamine-induced psychosis, imaging showed that LY379286,
glutamate receptor subtype 2 (mGluR2;
agonist, decreased hippocampal atrophy and hyperactivity compared with
vehicle. Next steps include scaling up clinical imaging studies to identify
at-risk patients and testing the effect of mGluR2 and/or mGluR3 modulators on
Eli Lilly and Co.'s Pomaglumetad
methionil, an oral prodrug of an mGlur2 and mGluR3 agonist, was
discontinued last year after missing the endpoints in a Phase III trial to
Therapeutics Ltd. and Taisho
Pharmaceutical Holdings Co. Ltd. have compounds in this class in
Phase I and II testing to treat various neuropsychiatric indications.
Published online May 2, 2013
status not applicable
Schobel, S.A. et al.
published online April 10, 2013;
Contact: Scott A. Small, Columbia University Medical Center,
New York, N.Y.
Contact: Holly Moore, same affiliation as above
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