Thursday, April 25, 2013
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Fibroblast growth factor receptor (FGFR)
fusions associated with multiple cancer types
Patient sample and mouse
studies identified FGFR fusions in multiple cancers and suggest
inhibiting such targets could have therapeutic benefit. Activating mutations
and amplifications of FGFR have previously been identified as drivers
in many cancers. In multiple cancer types including bladder, breast and
prostate cancer, rearrangements in FGFR were identified. In xenograft
mice with bladder cancer cells carrying FGFR3
fusions, a small molecule FGFR inhibitor decreased tumor growth compared with
vehicle. Next steps could include screening additional cancers for FGFR
At least six selective FGFR inhibitors are in Phase II testing or earlier to
treat various cancers.
Published online April 25, 2013
Patent and licensing status
Wu, Y.-M. et al. Cancer
Discov.; published online April 4, 2013;
Contact: Arul M. Chinnaiyan, University of Michigan, Ann
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